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David G. Lynn, PhD

Principle Investigator

           BA: University of Chapel Hill, NC

           PhD: Duke University, NC

           Post Doc: Columbia University, NY

David Lynn is an Asa Griggs Candler Professor in Chemistry and Biology and a Howard Hughes Medical Institute Professor at Emory University. His research deals with the origins of molecular order in the biosphere, and he serves as one of the founding members of the Advisory Board of the Atlanta Science Festival.

dlynn2@emory.edu

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Noel Li

Member since 2012

BS: Nanyang University, SG

I am looking at polymorphic structures of Aβ by seeding AD brain extracts into synthetic Aβ. Additionally, I am trying to understand the Aβ-tau interactions by cross-seeding and co-assembling Aβ and PHF6, the nucleating core of tau.

noel.li@emory.edu

LinkedIn

Siying Cen

Member since 2016

        BS: Wuhan University

My project aims to explore the relationship between bacteria and Alzheimer's disease, especially the influence of bacterial membrane glycolipids on amyloid peptides. Besides science, I am a fan of music.

 

 

 

 

siying.cen@emory.edu

Anthony Sementilli

Member since 2015

         BS: Saint Joseph's College, NY

My research focuses on using amyloids a novel bioelectronic materials. A third of all proteins rely on metal centers for functionality, but peptide assemblies can bind 1,000+ metals ions, like Cu(II), per structure. Achieving such a density of active metals along a ordered interface engenders these metallopeptides with catalytic properties such as peroxidase-like activity and reversible electron storage. In my spare time, I enjoy creative writing, baking, and  watching more TV shows than I can handle.

anthony.sementilli@emory.edu

LinkedIn

Member since 2011

             BS: China Pharmaceutical University, CN

         PhD: Emory University, GA

I study the structure and transition kinetics of amyloid assembly intermediates. Interfering with the assembly process re-directs the final structure. By identifying factors impacting normal modes, I advanced the methodology of using isotope edited infrared spectroscopy to study the kinetics of self-assembled materials. These insights provide new directions for improving nanomaterial design. My hobbies are dancing and volunteering.

cliang9@emory.edu

LinkedIn

Chen Liang, PhD

Yushi Bai, PhD

Member since 2016

          BS: Jilin University, CN

          PhD: Jilin University, CN

By modifying the peptide termini into reactive groups, we can build dynamic chemical networks (DCN) without enzymes. Such networks can be utilized to study self-evolutionary systems  and responsiveness to external templates. DCNs also feature versatility with a diverse peptide sequence pool; varying the sequences generate different peptide materials with distinctive properties in a dynamic, spontaneous way. In my spare time, I enjoy talking to friends over a cup of coffee, listening to music, and watching sports.

yushi.bai@emory.edu

Olga Taran, PhD

Member since 2016

                 BS/MS: Universidad Nacional Autonoma de Mexico, MX

             PhD: Ruhr-University Bocum, DE

             Post Doc: Harvard University, MA

I grew up in Kamchatka, Russia and moved to Mexico City with my family when I was 12. After completing my PhD, I went to Harvard where I was an Origins of Life postdoc in Prof. George M. Whitesides lab. I moved to Atlanta with my husband and son, and I am currently a postdoc in Lynn's group. My research interests are in the areas of Systems Chemistry, origins of life and biogeochemistry of quinones

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otarani@emory.edu

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Jackey Hsieh, PhD

Member since 2011

             BS: National Central University, TW

MS: National Taiwan University, TW

         PhD: Georgia Institute of Technology, GA

Proteins and peptides play important roles in our daily lives. My study is to experimentally analyze and mathematically model the behaviors of the peptide-based biopolymers and networks, specifically including the dynamic combinatorial networks, kinetics and transitions of peptide assembly, and catalytic peptide assembly.   

mhsieh34@gatech.edu

LinkedIn

Member since 2015

BS: Emory University, GA

I study how nucleic acids interact with amyloid assemblies and functionalize these networks. My past work includes creating a nuclease-sensitive amyloid-templated hydrogel and exploring a novel multilamellar nanotubes formed by DNA-peptide co-assemblies.  Currently, I am investigating the properties and structural identity of G-Quadruplex DNA-peptide chimera.  Because G-Quadruplexes have been implicated in charge transport, we hope this chimera could be used in bioelectronics. I'm also passionate about languages, food, and my dog, Daisy!

cdhamma@alumni.emory.edu

   

Christella Dhammaputri

Member since 2017

I'm the group's branch manager (see picture). I make sure all squirrels are off the premises and that the contents of our trash cans are delicious. I like taking long walks, getting pats, ​om-nomming sleeves, and attacking my own leash. All in all a fun-loving pupper.

crazy.daisy@woofmail.grr

Daisy

Member since 2016

          BS: Emory University (2018) 

In hope of designing an inside-out virus that can deliver functional prion protein into cells, I am working on the optimization of fluorophore-tagged nucleic acid and amyloid β peptide co-assembly.  Currently, I am trying to modify assembly condition for the co-assembly to achieve homogeneity and to synthesize unnatural amino acid that can better interact with nucleic acid. In addition to lab, I love free food, concerts, and funny socks. 

mandy.chan@emory.edu

Mandy Chan

Member since 2016

          BS: Emory University (2020)

I'm an undergraduate student in the College of Arts and Sciences with deep-rooted interests in chemistry and English literature. I study peptide-derived dynamic chemical networks with the intention of understanding the kinetics that foreshadow potential alternative biochemistries and the mechanisms underlying chemical evolution. I am also a previous SURE Fellow and a current Robert DeHaan Fellow.  

ronnie.festok@emory.edu

Ronnie Festok

Member since 2017

Lucy Eum

 

        BS: Georgia State University (2020)

Amyloid-β competes with insulin to bind insulin receptors (IR) by sharing a common pattern recognition motif. Since Aβ and insulin can fibrilize individually, both might co-assemble together into higher order structures. My research interest is to test the capability of co-assembly of Aβ and insulin and to study the orientation of the co-assembled fibers. Hopefully, the result will help understanding the connection between Aβ and insulin based on data collected on the co-assembled fibers. Fun fact: I'm a marching band piccoloist.

yoonjieum@gmail.com

Member since 2016

Anirudh Pigudu

 

        BS: Emory University (2020)

I am currently a sophomore at Emory University and I am majoring in Neuroscience and Behavioral Biology. My research interests include looking into structures of Aβ in AD extracts and understanding interactions between Aβ and the tau protein.

anirudh.pigudu@emory.edu