• Anthony Sementilli

Dynamic Peptide Systems Meets Catalysis

The Lynn Lab has taken Nature Chemistry by storm.

Chenrui and Tolu published two high-impact articles on dynamic and catalytic peptide systems, respectively.

These articles are extra special because we decided to publish them together. Why, you ask? Collectively, they collectively tell a grander story on the power of peptide materials. Tolu's work has shown that a simple peptide, Ac-KLVFFAL-NH2, can assemble into catalytic nanotubes that can break and build bonds on aromatic substrates, whereas Chenrui's work features a different peptide, H-NF-CHO, which can self-polymerize and form multi-phase networks.

So, we have one system that builds polymers and another that forms monomers. Perhaps a system that builds its own monomers is on its way?

Until then, a round of applause for Chenrui and Tolu--nice work!

H-NF-CHO forms its own monomer library that self-selects for templated assembly--just add water (and MeCN).

Ac-KLVFFAL-NH2 forms enzyme-like nanotubes--no ribosomes needed!

Also, GaTech featured these articles in their News Center. Check it out!

#PeptideAssemblies #ChemicalEvolution #Tolu #Chenrui #NatureChemistry

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