© Lynn Lab. Proudly created with Wix.com


Sort by: Peptide Assemblies | Chemical Evolution | Rhizosphere​​

  1. Rolando F. Rengifo, Joshua M. Brockman, Anthony Sementilli, Noel Xiang'An Li, Chen Liang, Anil K. Mehta, Khalid Salaita, David G. Lynn. (2017) Dynamics of amyloid granules in the oligomer cascade hypothesis. Journal of the American Chemical Society Communications. In preparation.

  2. Alexandra W. Fuller, Phoebe Young, B. Daniel Pierce, Jamie Kitson-Finuff, Purvi Jain, Karl Schneider, Stephen Lazar, Olga Taran, Andrew G. Palmer, David G. Lynn. (2017). Redox-mediated quorum sensing in plants. Plos One. 12 (9). https://doi.org/10.1371/journal.pone.0182655. pdf

  3. Rolando F. Rengifo, Noel Xiang'An Li, Anthony Sementilli, David G. Lynn. (2017) Amyloid Scaffolds as Alternative Chlorosomes. Journal of Organic and Biomolecular Chemistry. 15. 7063-71. doi:10.1039/C7OB01170A pdf

  4. Ming-Chien Hsieh, David G. Lynn, Martha A. Grover. (2017) A kinetic model for two-step nucleation of peptide assembly. Journal of Physical Chemistry. 121 (31). doi: 7401-11. 10.1021/acs.jpcb.7b03085. pdf

  5. Olga Taran. (2017) Electron transfer between electrically conductive minerals and quinones. Fronteirs in Chemistry. 5 (49). 1-13.  doi:10.3389/fchem.2017.00049 pdf

  6. Jillian E. Smith-Carpenter, Sha Li, Jay T. Goodwin, Anil K. Mehta, David G. Lynn. (2017) On the Emerging Codes for Chemical Evolution. In: From Matter to Life--Information and Causality. Walker, S.I.,  Cambridge University Press, Cambridge, UK, 2017, 97-114. pdf

  7. Tolulope O. Omusun, Ming-Chien Hsieh, W. Seth Childers, Dibyendu Das, Anil. K. Mehta, Neil R. Anthony, Ting Pan, Martha A. Grover, Keith M. Berland, David G. Lynn. (2017) Catalytic diversity in self-propagating peptide assemblies. Nature Chemistry, 9. 805-9. doi:10.1038/nchem.2738

  8. Chenrui Chen, Junjun Tan, Ming-Chien Hsieh, Ting Pan, Jay T. Goodwin, Anil K. Mehta, Martha A. Grover, David G. Lynn. (2017) Design of Multi-Phase Dynamic Chemical Networks. Nature Chemistry. 9. 799-804. doi:10.1038/nchem.2737. pdf

  9. Sha Li, Anil K. Mehta, Anton N. Sidorov, Thomas M. Orlando, Zhigang Jang, Neil R. Anthony, and David G. Lynn. (2016) Design of Asymmetric Peptide Bilayer Membranes. Journal of the American Chemical Society, 138 (10). 3579-86. doi:10.1021/jacs.6b00977. pdf

  10. Fang Fang, Yi-Han Lin, B. Daniel Pierce & David Lynn. (2015). A Rhizobium radiobacter histidine kinase can employ both Boolean AND and OR logic gates for initiating pathogenesis. ChemBioChem, , n/a-n/a, doi:10.1002/cbic.201500334.

  11. Jillian E. Smith; Chen Liang; Michael Tseng; Noel Li; Sha Li; Allisandra K. Mowles; Anil K. Mehta; David G. Lynn (2015). Defining the Dynamic Conformational Networks of Cross-β Peptide Assembly. Israel Journal of Chemistry, 763-9. doi: 10.1002/ijch.201500012. (pre submission pdf)

  12. Jillian E. Smith, Allisandra K. Mowles, Anil K. Mehta, David G. Lynn, (2014). Looked at Life from Both Sides Now.Life 4: 887–902: doi: 10.1021/ja508621b (Open Access)

  13. Chen Liang, Rong Ni, Jillian E. Smith, W. Seth Childers, Anil K. Mehta, David G. Lynn, (2014). Kinetic Intermediates in Amyloid Assembly.J. Am. Chem. Soc 136: 15146–15149: doi: 10.1021/ja508621b (pre submission pdf)

  14. Sha Li; Anton N. Sidorov; Anil K. Mehta; Anthony J. Bisignano; Dibyendu Das; W. Seth Childers; Erin Schuler; Zhigang Jiang; Thomas M. Orlando; Keith Berland; David G. Lynn, (2014). Neurofibrillar Tangle Surrogates: Histone H1 Binding to Patterned Phosphotyrosine Peptide Nanotubes. Biochemistry 53: 4225-4227. (pre submission pdf)

  15. Goodwin JT, Lynn DG. (2014) Holistic Education in Times of Specialization and Globalization. Angew Chem, Int Ed. 53:6832-6832. doi: 10.1002/anie.201400597.

  16. Lin Y-H, Pierce BD, Fang F, Wise A, Binns A, Lynn D. (2014) Role of the VirA histidine autokinase of Agrobacterium tumefaciens in the initial steps of pathogenesis. Frontiers in Plant Science.;5: article 195 p1-doi: 10.3389/fpls.2014.00195.

  17. Neil R.Anthony, Anil K. Mehta, David G. Lynn and Keith M. Berland (2014) Mapping amyloid-ß(16-22) nucleation pathways using fluorescence lifetime imaging microscopy. Soft Matter, 10: 4162-4172, pdf.

  18. Qiaohang Guo, Anil K. Mehta, Martha A Grover, Wenzhe Chen, David G. Lynn and Zi Chen. (2014) Shape Selection and Multi-stability in Helical Ribbons. Applied Physics Letters,104(21):211102. pdf from arxiv.org

  19. Jillian E. Smith, Allisandra K. Rha, Anil K. Mehta, David G. Lynn. (2014) Looked at life from both sides now. Life, 4(4): 887-902. doi:10.3390/life4040887  

  20. Neil R. Anthony, Keith M. Berland, Anil K. Mehta, W. Seth Childers and David G. Lynn, (2014). Imaging Nucleation, Growth and Heterogeneity in Self-Assembled Amyloid Phases. In: Uversky VN, Lyubchenko YL, editors. Bio-nanoimaging. Boston: Academic Press; 2014. p. 27-36. pdf

  21. Anil K. Mehta, Rebecca F. Rosen, W. Seth Childers, John D. Gehman, Lary C. Walker and David G. Lynn (2013). Context dependence of protein misfolding and structural strains in neurodegenerative diseases. Biopolymers, 100: 722-730. PMC full text

  22. Jessica Hernández-Guzmán, Li Sun, Anil K. Mehta, Jijun Dong, David G. Lynn and Kurt Warncke (2013). Copper(II)-bis-Histidine Coordination Structure in a Fibrillar Amyloid β-Peptide Fragment and Model Complexes Revealed by Electron Spin Echo Envelope Modulation Spectroscopy. ChemBioChem, 14: 1762-1771. PMC full text

  23. David G. Lynn, Cynthia J. Burrows, Jay T Goodwin and Anil K. Mehta (2012). Origins of Chemical Evolution, Accounts of Chemical Research, 45: 2023–2024.

  24. Rong Ni, W. Seth Childers, Kenneth I. Hardcastle, Anil K. Mehta and David G. Lynn (2012). Remodeling Cross-ß Nanotube Surfaces with Peptide/Lipid Chimeras. Angewandte Chemie International Edition, 51: 6635-6638.

  25. W. Seth Childers, Anil K. Mehta, Thinh Q. Bui, Yan Liang and David G. Lynn (2012). Toward Intelligent Material, In Molecular Self-Assembly - Advances and Applications. ; 1st ed.; Li, A., Ed.; Pan Stanford Publishing Pte Ltd: Singapore/SG, 2012; pp 1-36. pdf

  26. Jay T Goodwin, Anil K. Mehta and David G. Lynn (2012). Digital and Analog Chemical Evolution. Acc Chem Res, 45: 2189-2199.

  27. W. Seth Childers, Neil R. Anthony, Anil K. Mehta, Keith M. Berland and David G. Lynn (2012). Phase Networks of Cross-β Peptide Assemblies. Langmuir, 28: 6386-6395.

  28. Lakshmi N. Anumukonda, Avery Young, David G. Lynn, Ragan Buckley, Amena Warrayat, Christina L. Graves, Heather D. Bean, and Nicholas V. Hud (2011). Adenine Synthesis in a Model Prebiotic Reaction: Connecting Origin of Life Chemistry with Biology. J Chem Ed, 88: 1698-1701.

  29. W. A. Anderson, R. M. Amasino, M. Ares, U. Banerjee, B. Bartel, V. G. Corces, C. L. Drennan, S. C. R. Elgin, I. R. Epstein, E. Fanning, L. J. Guillette, J. Handelsman, G. F. Hatfull, R. R. Hoy, D. Kelley, L. A. Leinwand, R. Losick, Y. Lu, D. G. Lynn, C. Neuhauser, D. K. O'Dowd, T. Olivera, P. Pevzner, R. R. Richards-Kortum, J. Rine, R. L. Sah, S. A. Strobel, G. C. Walker, D. R. Walt, I. M. Warner, S. Wessler, H. F. Willard and R. N. Zare (2011). Competencies: A Cure for Pre-Med Curriculum. Science, 334: 760-761.

  30. Xiaoyu Li, Andres F. Hernandez, Martha A. Grover, Nicholas V. Hud and David G. Lynn (2011). Step-Growth Control in Template-Directed PolymerizationHeterocycles, 82(2): 1477-1488. pdf

  31. W. Seth Childers, Anil K. Mehta, Rong Ni, Jeannette V. Taylor and David G. Lynn (2010). Peptides Organized as Bilayer Membranes. Angewandte Chemie International Edition , 49: 4104-4107.

  32. Horowitz ED, Engelhart AE, Chen MC, Quarles KA, Smith MW, Lynn DG, Hud NV.(2010). Intercalation as a means to suppress cyclization and promote polymerization of base-pairing oligonucleotides in a prebiotic world., Proceedings of the National Academy of Sciences, 107: 5288–5293.

  33. Yan Liang, David G. Lynn, Keith M. Berland (2010). Direct Observation of Nucleation and Growth in Amyloid Assembly, Journal of the american Chemical Society. 132: 6306–6308.

  34. Arlene A. Wise, Fang Fang, Yi-Han Lin, Fanglian He, David G. Lynn and Andrew N. Binns (2010). The Receiver Domain of Hybrid Histidine Kinase VirA: an Enhancing Factor for vir Gene Expression in Agrobacterium tumefaciens, J Bacteriol., 192: 1534-1542.

  35. W. Seth Childers, Anil K. Mehta, Rong Ni and David G. Lynn (2009). Peptide Membranes in Chemical Evolution, Current Opinion in Chemical Biology, 2009, 13: 652-659.

  36. W. Seth Childers, Anil K. Mehta, Kun Lu and David G. Lynn (2009). Templating Molecular Arrays in Amyloid's Cross-ß Grooves, J. Am. Chem. Soc., 2009, 131 10165–10172

  37. Palmer AG, Chen MC, Kinger NP, and Lynn DG Parasitic angiosperms, semagenesis and general strategies for plant-plant signaling in the rhizosphere (2009) Pest Manag Sci

  38. Yi-Han Lin, Rong Gao, Andrew N. Binns and David G. Lynn (2008). Capturing the VirA/VirG TCS of Agrobacterium tumefaciens. Advances in experimental medicine and biology;63:161-77

  39. Yan Liang, Peng Guo, Sai Venkatesh Pingali, Suzette Pabit, Pappannan Thiyagarajan, Keith M. Berland and David G. Lynn (2008). Light Harvesting Antenna on an Amyloid Scaffold, Chem. Commun., 2008, 6522 - 6524.

  40. Peng Liu, Rong Ni, Anil K. Mehta, W. Seth Childers, Ami Lakdawala, Sai Venkatesh Pingali, Pappannan Thiyagarajan and David G. Lynn (2008). Nucleobase-Directed Amyloid Nanotube Self-Assembly, J. Am. Chem. Soc . 130: 9829-9835

  41. Yan Liang, Sai Venkatesh Pingali, Ashutosh S. Jogalekar, James P. Snyder, Pappannan Thiyagarajan, and David G. Lynn (2008). Cross-Strand Pairing and Amyloid Assembly Biochemistry 47(38): 10018-10026

  42. Anil K. Mehta, Kun Lu, W. Seth Childers, Yan Liang, Steven N. Dublin, Jijun Dong, James P. Snyder, Sai Venkatesh Pingali, Pappannan Thiyagarajan, and David G. Lynn (2008) Facial Symmetry in Protein Self-Assembly J. Am. Chem. Soc . 130: 9829-9835

  43. Palmer AG, Yue Liu, Samantha M Adkins, Xiao Zhang, I-Lin Wu, Xianyu Chen and David G. Lynn The molecular language of semagenesis (2008) Plant Signal Behav. 3(47), 560-561

  44. Yi-Han Lin, Andrew N. Binns and David G. Lynn (2008). The Initial Steps in Agrobacterium Tumefaciens Pathogenesis: Chemical Biology of Host Recognition.Agrobacterium: From Biology to Biotechnology, 221-241, DOI: 10.1007/978-0-387-72290-0_6

  45. Jijun Dong, Jesse D. Bloom, Vladimir Goncharov, Madhuri Chattopadhyay, Glenn L. Millhauser, David G. Lynn, Thomas Scheibel and Susan Lindquist Probing the Role of PrP Repeats in Conformational Conversion and Amyloid Assembly of Chimeric Yeast Prion. (2007) J. Biol. Chem. 282(47), 34204-34212

  46. Jijun Dong, Jeffrey M. Canfield, Anil K. Mehta, Jacob E. Shokes, Bo Tian, W. Seth Childers, James A. Simmons, Zixu Mao, Robert A. Scott, Kurt Warncke, and David G. Lynn (2007). Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity. Proc. Nat. Acad. Sci. 104(33): 13313-13318

  47. Kun Lu, Liang Guo, Anil K. Mehta, W. Seth Childers, Steven N. Dublin, S. Skanthakumar, Vincent P. Conticello, P. Thiyagarajan, Robert P. Apkarian and David G. Lynn (2007). "Macroscale assembly of peptide nanotubes ." Chem. Com. 2729-2731

  48. Keyes WJ, Palmer AG, Erbil WK, Taylor JV, Apkarian RP, Weeks ER, Lynn DG (2007). "Semagenesis and the parasitic angiosperm Striga asiatica." Plant J. 51(4):707–716

  49. Gao R, Lynn DG. (2007). "Integration of Rotation and Piston Motions in Coiled-Coil Signal Transduction." J. Bacteriol 189(16):6048-6056

  50. Maresh J, Zhang J, Tzeng YL, Goodman NA, Lynn DG. (2007). "Rational design of inhibitors of VirA-VirG two-component signal transduction.." Bioorg Med Chem Lett. 17(12):3281-3286

  51. Hud NV, Jain SS, Li X, Lynn DG. (2007). "Addressing the problems of base pairing and strand cyclization in template-directed synthesis: a case for the utility and necessity of 'molecular midwives' and reversible backbone linkages for the origin of proto-RNA." Chem Biodivers. 4(4):768-83.

  52. Maresh, J.; Zhang, J., Lynn DG (2006). "The Innate Immunity of Maize: Dynamic Chemical Strategies Regulating Two-Component Signal Transduction in Agrobacterium tumefaciens." ACS Chemical Biology, 1(3), 165-175.

  53. Dong J, Lu K, Lakdawala A, Mehta AK, Lynn DG (2006). "Controlling Amyloid Growth in Multiple Dimensions ." Amyloid 13(4): 306 - 215.

  54. Gao R, Mukhopadhyay A, Fang F, Lynn DG. (2006). "Constitutive activation of two-component response regulators: characterization of VirG activation in Agrobacterium ." J. Bacteriol., 188: 5204-5211.

  55. Dong J., Shokes JE, et al. (2006). "Modulating Amyloid Self-Assembly and Fibril Morphology with Zn(II) ." J. Am. Chem. Soc. 128: 3540 - 3542.

  56. Gao, R. and Lynn, D.G. (2005). "Environmental pH Sensing: Resolving the VirA/VirG Two-component System Inputs for Agrobacterium Pathogenesis." J. Bacteriol. 187: 2182-2189.

  57. Dong, Jijun; Apkarian, Robert P, et al. (2005). "Imaging amyloid beta peptide oligomeric particles in solution ." Bioorganic & Medicinal Chemistry, 13(17), 5213-5217.

  58. Palmer, A.G.; Gao, R., et al. (2004). "CHEMICAL BIOLOGY OF MULTI-HOST/PATHOGEN INTERACTIONS: Chemical Perception and Metabolic Complementation." Ann. Rev. Phytopathology, 42: 439-64

  59. Lu, Kun; Conticello, Vincent P., et al. (2004). "Templating Colloidal Metal Nanoparticle Assemblies: Use of the A beta Amyloid Peptide Nanotube." Mater. Res. Soc. Synp. Proc , V 1.6

  60. Hud, N.V.; Lynn, D.G. (2004). "Model systems: From life's origins to a synthetic biology. ." Cur Op. Chem. Biol. 8: 627.

  61. Mukhopadhyay, A.; Gao, R., et al. (2004). "Integrating inputs from Multiple Signals: The VirA/VirG Two Component system of Agrobacterium tumefaciens." ChemBioChem,1535-42

  62. Lu, Kun; Jacob, Jaby, et al. (2003). "Exploiting Amyloid Fibril Lamination for Nanotube Self-Assembly ." Journal of the American Chemical Society, 125(21), 6391-6393.

  63. Lynn DG, Snyder JP, et al. (2003). "Conformational evolution: the wiggling of peptides into amyloid ." Structure 11(3):242.

  64. Ami S. Lakdawala, David M. Morgan, et al. (2002). "Dynamics and fluidity of amyloid fibrils: A model of fibrous protein aggregates." Journal of the American Chemical Society.; 124(51) pp 15150 - 15151.

  65. David M. Morgan, Jijun Dong, et al. (2002). "Metal Switch for Amyloid Formation: Insight into the Structure of the Nucleus." Journal of the American Chemical Society.; 124(43) pp 12644 - 12645.

  66. Li, X. and D. G. Lynn (2002). "Polymerization on Solid Supports." Angewandte Chemie 41: 4567-69

  67. Li, X., Z.-Y. J. Zhan, et al. (2002). "DNA-Catalyzed Polymerization." Journal of the American Chemical Society 124(5): 746-747.

  68. Morgan, D. M., D. G. Lynn, et al. (2002). "Amyloid structure: models and theoretical considerations in fibrous aggregates." Journal of the Chinese Chemical Society(Taipei, Taiwan) 49(4): 459-466.

  69. Wang, Y., R. Gao, et al. (2002). "Ratcheting up vir gene expression in Agrobacterium tumefaciens: coiled coils in histidine kinase signal transduction." ChemBioChem3(4): 311-317.

  70. Keyes, W. J., J. V. Taylor, et al. (2001). "Dancing together: Social controls in parasitic plant development." Plant Physiology 127(4): 1508-1512.

  71. Leitzel, J. C. and D. G. Lynn (2001). "Template-directed ligation: from DNA towards different versatile templates." Chemical Record 1(1): 53-62.

  72. Morgan, D. M., D. G. Lynn, et al. (2001). "A Designed Zn2+ Binding Amphiphilic Polypeptide: Energetic Consequences of π-Helicity." Biochemistry 40(46): 14020-14029.

  73. Zhan, Z.-Y. J., J. Ye, et al. (2001). "Replicating DNA differently." Current Organic Chemistry 5(8): 885-902.

  74. Gat, Y. and D. G. Lynn (2000). "Template-directed ligation: towards the synthesis of sequence specific polymers." In Templated Organic Synthesis. Edited by Stang P, Diederich F. Wiley-VCH: pp133-157.

  75. Keyes, W. J., R. C. O'Malley, et al. (2000). "Signaling organogenesis in parasitic angiosperms: xenognosin generation, perception, and response." Journal of Plant Growth Regulation 19(2): 217-231.

  76. Kim, S.-H., R. Wang, et al. (2000). "Familial British dementia: Expression and metabolism of BRI." Annals of the New York Academy of Sciences 920(Molecular Basis of Dementia): 93-99.

  77. Lynn, D. G. and S. C. Meredith (2000). "Review: Model Peptides and the Physicochemical Approach to β-Amyloids." Journal of Structural Biology 130(2/3): 153-173.

  78. O'Malley, R. C. and D. G. Lynn (2000). "Expansion message regulation in parasitic angiosperms: marking time in development." Plant Cell 12(8): 1455-1465.

  79. Thiyagarajan, P., T. S. Burkoth, et al. (2000). "pH dependent self assembly of β-amyloid(10-35) and β-amyloid(10-35)-PEG3000." Journal of Applied Crystallography 33(3, Pt. 1): 535-539.

  80. Wang, Y., A. Mukhopadhyay, et al. (2000). "Construction of an efficient expression system for Agrobacterium tumefaciens based on the coliphage T5 promoter." Gene242(1-2): 105-114.

  81. Ye, J., Y. Gat, et al. (2000). "Catalyst for DNA ligation: towards a two-stage replication cycle." Angewandte Chemie, International Edition 39(20): 3641-3643.

  82. Zhang, J., L. Boone, et al. (2000). "At the maize/Agrobacterium interface: natural factors limiting host transformation." Chemistry & Biology 7(8): 611-621.

  83. Benzinger, T. L. S., D. M. Gregory, et al. (2000). "Two-Dimensional Structure of β-Amyloid(10-35) Fibrils." Biochemistry 39(12): 3491-3499.

  84. Burkoth, T. S., T. L. S. Benzinger, et al. (2000). "Structure of the β-Amyloid(10-35) Fibril." Journal of the American Chemical Society 122(33): 7883-7889.

  85. Campbell, A. M., J. B. Tok, et al. (2000). "Xenognosin sensing in virulence: is there a phenol receptor in Agrobacterium tumefaciens?" Chemistry & Biology 7(1): 65-76.